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榪戞棩錛屾嘲宸炲競(jìng)緹庢⒌寰＄敓鐗╂妧鏈湁闄愬叕鍙革紙浠ヤ笅綆�縐?/span>鈥滅編姊靛盡鐢熺墿鍏徃鈥濓級(jí)涓庡崡鏂瑰尰縐戝ぇ瀛︾殑瀛ｇ埍姘戞暀鎺堝洟闃熷甯冿紝鍦ㄦ牳緋栨牳閰革紙RNA錛夌鏂戠編鐧介鍩熷彇寰椾簡(jiǎn)閲嶅ぇ鍚堜綔榪涘睍銆傝繖涓�紿佺牬鎬х殑鎴愭灉鏈夋湜涓虹鏂戠編鐧藉競(jìng)鍦哄甫鏉ュ叏鏂扮殑瑙ｅ喅鏂規(guī)錛屼負(fù)娑堣垂鑰呮彁渚涙洿鍔犲畨鍏ㄣ�侀珮鏁堢殑緹庣櫧浜у搧銆?/span>
緹庢⒌寰＄敓鐗╁叕鍙革紝鎴愮珛浜?/span>2024騫達(dá)紝鏄竴瀹朵互浠庝簨鍖栧鍝佸強(qiáng)鍖昏嵂鍒墮�犱笟涓轟富鐨勪紒涓氾紝涓撴敞浜庣敓鐗╂妧鏈殑鐮斿彂涓庡簲鐢ㄣ�傚叕鍙歌嚧鍔涗簬閫氳繃鍏堣繘鐨勭鎶�鎵嬫錛屼負(fù)娑堣垂鑰呮彁渚涢珮鍝佽川鐨勫仴搴峰拰緹庡浜у搧銆傛嬈′笌瀛ｇ埍姘戞暀鎺堝洟闃熺殑鍚堜綔錛屾鏄編姊靛盡鐢熺墿鍏徃鍦ㄧ編瀹規(guī)姢鑲ら鍩熺殑涓�嬈￠噸瑕佹帰绱€�?/span>
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鏍哥硸鏍擱吀錛?/span>RNA錛夊湪铔嬬櫧璐ㄥ悎鎴愯繃紼嬩腑璧風(fēng)潃閲嶈浣滅敤錛屽叾涓皬騫叉壈鏍哥硸鏍擱吀錛坰iRNA錛夎兘澶熷共鎵板熀鍥犺〃杈撅紝浠庤�屽疄鐜板鐗瑰畾鍩哄洜鐨勬矇榛樸�傝繎騫存潵錛岃秺鏉ヨ秺澶氱殑鐮旂┒琛ㄦ槑錛宻iRNA鍦ㄦ姂鍒墮粦鑹茬礌鐢熸垚鏂歸潰鍏鋒湁鏄捐憲鏁堟灉銆傞�氳繃闈跺悜璋冩帶鎴愭枒鍩哄洜錛宻iRNA鑳藉浠庢簮澶撮樆鏂粦鑹茬礌鐨勭敓鎴愶紝杈懼埌紲涙枒緹庣櫧鐨勭洰鐨勩�?/span>
緹庢⒌寰＄敓鐗╁叕鍙鎬笌瀛ｇ埍姘戞暀鎺堝洟闃熺殑鍚堜綔錛屾鏄熀浜庤繖涓�鍘熺悊銆傚弻鏂瑰叡鍚岀爺鍙戜簡(jiǎn)涓�嬈懼叏鏂扮殑紲涙枒緹庣櫧浜у搧錛岃浜у搧閲囩敤浜?jiǎn)鍏垬q涚殑siRNA鎶�鏈紝閫氳繃闈跺悜璋冩帶鎴愭枒鍩哄洜錛屼粠婧愬ご瑙ｅ喅鑲岃偆鏆楁矇闂銆傚悓鏃訛紝浜у搧榪橀噰鐢ㄤ簡(jiǎn)瓚呭井鑴傚泭閫忕毊鎶�鏈紙鑴傝川浣撳寘瑁規(guī)妧鏈級(jí)錛岀‘淇漵iRNA鐨勭ǔ瀹氭�у拰閫忕毊鏁堢巼錛屼嬌鍏惰兘澶熷畨鍏ㄦ姷杈捐倢搴曞茍娣卞叆榛戣壊绱犵敓鎴愮殑鍐呴儴銆?/span>
緇忚繃澶氭瀹為獙鍜屼復(fù)搴婇獙璇侊紝璇ヤ駭鍝佸湪紲涙枒緹庣櫧鏂歸潰琛ㄧ幇鍑轟簡(jiǎn)鏄捐憲鐨勬晥鏋溿�備笌浼犵粺緹庣櫧浜у搧鐩告瘮錛岃浜у搧涓嶄粎紲涙枒鏁堢巼鏇撮珮錛岃�屼笖浜у搧瀹夊叏銆佷笉榪囨晱錛屼笉娣誨姞閲嶉噾灞炪�佹縺绱犵瓑鏈夊鐗╄川錛屽鑲岃偆鏇村姞娓╁拰銆?/span>
緹庢⒌寰＄敓鐗╁叕鍙歌〃紺猴紝姝ゆ涓庡鐖辨皯鏁欐巿鍥㈤槦鐨勫悎浣滄槸鍏徃鍙戝睍鍘嗙▼涓殑涓�嬈￠噸瑕侀噷紼嬬銆傛湭鏉ワ紝鍏徃灝嗙戶緇姞澶у湪鐢熺墿鎶�鏈鍩熺殑鐮斿彂鎶曞叆錛屼笌鏇村浼樼鐨勭鐮斿洟闃熷紑灞曞悎浣滐紝涓烘秷璐硅�呮彁渚涙洿澶氶珮鍝佽川鐨勫仴搴峰拰緹庡浜у搧銆?/span>
瀛ｇ埍姘戞暀鎺堜篃瀵硅繖涓�鍚堜綔鎴愭灉琛ㄧず浜?jiǎn)楂樺害璁ゅ彲銆備粬琛ㄧず錛?/span>RNAi鎶�鏈湪紲涙枒緹庣櫧棰嗗煙鐨勫簲鐢ㄥ叿鏈夊箍闃旂殑鍓嶆櫙錛屾湭鏉ユ湁鏈涗負(fù)鏇村娑堣垂鑰呭甫鏉ョ編涓藉拰鑷俊銆?/span>
姝ゆ緹庢⒌寰＄敓鐗╁叕鍙鎬笌瀛ｇ埍姘戞暀鎺堝洟闃熷湪鏍哥硸鏍擱吀紲涙枒緹庣櫧鏂歸潰鐨勫悎浣滄垚鏋滐紝涓嶄粎涓虹鏂戠編鐧藉競(jìng)鍦哄甫鏉ヤ簡(jiǎn)鏂扮殑紿佺牬錛屼篃涓虹敓鐗╂妧鏈湪緹庡鎶よ偆棰嗗煙鐨勫簲鐢ㄦ彁渚涗簡(jiǎn)鏂扮殑鎬濊礬銆傜浉淇″湪涓嶄箙鐨勫皢鏉ワ紝榪欎竴鎶�鏈皢浼?xì)湄?fù)鏇村娑堣垂鑰呭甫鏉ョ編涓藉拰鍋ュ悍銆?/span>