緹庢⒌寰＄敓鐗╁叕鍙稿埄鐢ㄦ牳緋栨牳閰稿厛榪涚殑宸ヨ壓鎶�鏈湪紲涙枒緹庣櫧璧涢亾寮�鍚柊綃囩珷
榪戞棩錛岀編姊靛盡鐢熺墿鍏徃瀹ｅ竷鍦ㄧ鏂戠編鐧介鍩熷彇寰椾簡閲嶅ぇ紿佺牬錛屾垚鍔熷埄鐢ㄦ牳緋栨牳閰革紙RNA錛夊厛榪涚殑宸ヨ壓鎶�鏈紝寮�鍚簡紲涙枒緹庣櫧璧涢亾鐨勬柊綃囩珷銆傝繖涓�鎴愭灉鏍囧織鐫�緹庢⒌寰?/span>鐢熺墿鍏徃鍦ㄧ敓鐗╃鎶�緹庡棰嗗煙榪堝嚭浜嗗潥瀹炵殑姝ヤ紣錛屼負娑堣垂鑰呭甫鏉ヤ簡鏇村姞瀹夊叏銆侀珮鏁堢殑緹庣櫧浜у搧銆?/span>
緹庢⒌寰?/span>鐢熺墿鍏徃錛屼綔涓虹敓鐗╃鎶�棰嗗煙鐨勪郊浣艱�咃紝涓�鐩磋嚧鍔涗簬灝嗗厛榪涚殑鐢熺墿縐戞妧搴旂敤浜庣編瀹規(guī)姢鑲ら鍩熴�傛嬈★紝鍏徃鍒╃敤鏍哥硸鏍擱吀鎶�鏈紝閫氳繃綺懼噯璋冩帶榛戣壊绱犵敓鎴愯繃紼嬩腑鐨勫叧閿熀鍥狅紝瀹炵幇浜嗕粠婧愬ご紲涙枒緹庣櫧鐨勬晥鏋溿�?/span>
鏍哥硸鏍擱吀錛?/span>RNA錛変綔涓虹敓鐗╀綋鍐呴噸瑕佺殑淇℃伅浼犻�掑垎瀛愶紝鍦ㄥ熀鍥犺〃杈捐皟鎺т腑鍙戞尌鐫�鍏抽敭浣滅敤銆?span style="color: #05073B; font-family: "Segoe UI"; font-size: 15px;">緹庢⒌寰?/span>鐢熺墿鍏徃鍒╃敤RNA騫叉壈錛圧NAi錛夋妧鏈紝璁捐騫跺悎鎴愪簡鑳藉鐗瑰紓鎬ч澏鍚戦粦鑹茬礌鐢熸垚鐩稿叧鍩哄洜鐨勫皬騫叉壈鏍哥硸鏍擱吀錛坰iRNA錛夈�傝繖浜泂iRNA鍒嗗瓙鑳藉榪涘叆緇嗚優(yōu)鍐呴儴錛屼笌鐩爣鍩哄洜緇撳悎騫跺共鎵板叾琛ㄨ揪錛屼粠鑰屾湁鏁堟姂鍒墮粦鑹茬礌鐨勭敓鎴愩�?/span>
涓轟簡紜繚siRNA鐨勭ǔ瀹氭�у拰閫忕毊鏁堢巼錛?span style="color: #05073B; font-family: "Segoe UI"; font-size: 15px;">緹庢⒌寰?/span>鐢熺墿鍏徃榪橀噰鐢ㄤ簡鍏堣繘鐨勭撼綾寵澆浣撴妧鏈�傝繖浜涚撼綾寵澆浣撹兘澶熷寘瑁箂iRNA鍒嗗瓙錛屼繚鎶ゅ叾鍏嶅彈浣撳唴鐜鐨勫獎鍝嶏紝騫舵湁鏁堜績榪涘叾鍦ㄧ毊鑲ょ粍緇囦腑鐨勬笚閫忓拰鍒嗗竷銆傞�氳繃榪欑鏂瑰紡錛宻iRNA鑳藉鏇村噯紜湴鍒拌揪鐩爣緇嗚優(yōu)錛屽茍鍙戞尌鍏剁鏂戠編鐧界殑鏁堟灉銆?/span>
緇忚繃澶氭瀹為獙鍜屼復搴婇獙璇侊紝緹庢⒌寰?/span>鐢熺墿鍏徃鍒╃敤鏍哥硸鏍擱吀鎶�鏈紑鍙戠殑紲涙枒緹庣櫧浜у搧琛ㄧ幇鍑轟簡鏄捐憲鐨勬晥鏋溿�備笌浼犵粺緹庣櫧浜у搧鐩告瘮錛岃浜у搧涓嶄粎紲涙枒鏁堢巼鏇撮珮錛岃�屼笖瀹夊叏鎬ф洿楂橈紝涓嶄細瀵圭毊鑲ら�犳垚浠諱綍鍒烘縺鍜屾崯浼ゃ�傚悓鏃訛紝璇ヤ駭鍝佽繕鍏鋒湁鑹ソ鐨勭ǔ瀹氭�у拰鎸佷箙鎬э紝鑳藉闀挎湡淇濇寔緹庣櫧鏁堟灉銆?/span>
緹庢⒌寰?/span>鐢熺墿鍏徃琛ㄧず錛屾嬈″埄鐢ㄦ牳緋栨牳閰告妧鏈湪紲涙枒緹庣櫧棰嗗煙鍙栧緱鐨勭獊鐮達紝鏄叕鍙擱暱鏈熸姇鍏ョ敓鐗╃鎶�鐮斿彂鐨勭粨鏋溿�傛湭鏉ワ紝鍏徃灝嗙戶緇姞澶у湪鐢熺墿縐戞妧棰嗗煙鐨勭爺鍙戞姇鍏ワ紝涓嶆柇鎺㈢儲鍜屽垱鏂幫紝涓烘秷璐硅�呭甫鏉ユ洿澶氶珮鍝佽川鐨勫仴搴峰拰緹庡浜у搧銆?/span>
姝ゅ錛?span style="color: #05073B; font-family: "Segoe UI"; font-size: 15px;">緹庢⒌寰?/span>鐢熺墿鍏徃榪樺己璋冿紝鍦ㄨ拷姹傜編鐧芥晥鏋滅殑鍚屾椂錛屾洿娉ㄩ噸浜у搧鐨勫畨鍏ㄦ�у拰鏈夋晥鎬с�傚叕鍙稿皢緇х畫縐夋壙鈥滅瀛︺�佸畨鍏ㄣ�侀珮鏁堚�濈殑鐮斿彂鐞嗗康錛屼負娑堣垂鑰呮彁渚涙洿鍔犲畨鍏ㄣ�佸彲闈犵殑緹庣櫧浜у搧銆?/span>
緇間笂鎵�榪幫紝緹庢⒌寰?/span>鐢熺墿鍏徃鍒╃敤鏍哥硸鏍擱吀鍏堣繘鐨勫伐鑹烘妧鏈湪紲涙枒緹庣櫧璧涢亾涓婂彇寰椾簡閲嶅ぇ紿佺牬銆傝繖涓�鎴愭灉涓嶄粎涓烘秷璐硅�呭甫鏉ヤ簡鏇村姞瀹夊叏銆侀珮鏁堢殑緹庣櫧浜у搧錛屼篃涓虹敓鐗╃鎶�緹庡棰嗗煙鐨勫彂灞曟敞鍏ヤ簡鏂扮殑媧誨姏銆傜浉淇″湪涓嶄箙鐨勫皢鏉ワ紝緹庢⒌寰?/span>鐢熺墿鍏徃灝嗙戶緇紩棰嗙敓鐗╃鎶�緹庡棰嗗煙鐨勫彂灞曟疆嫻侊紝涓烘秷璐硅�呭甫鏉ユ洿澶氭儕鍠滃拰鏈熷緟銆?/span>